Plasmid contains the entire genome of HIV-1 with a specific mutation in the protease gene, which has been described as a polymorphic mutation. It is unclear, whether it can confer drug resistance to specific HIV-1 PR inhibitors directly. It has been shown in cell culture that the presence of the 63P change leads to higher "replicative fitness" of the virus. The respective mutations have been reported in viruses from HIV-infected individuals on PR inhibitors with virologic therapy failure.
Virus was produced from plasmid-based DNA segments of a common Wuhan strain. The S-gene was site-specifically replaced with a cloned BA.5-based S-gene sequence.
Virus has been produced from plasmid-based DNA segments of a common Wuhan strain. The S-gene was site-specifically replaced with a cloned BA.2-based S-gene sequence.
Virus was produced from plasmid-based DNA segments of a common Wuhan strain. The S-gene was site-specifically replaced with a cloned BA.1-based S-gene sequence.
plasmid encoding the VSV antigenome, lacking the G gene, and encoding mCherry, for producing recombinant VSV lacking a glycoprotein for pseudotyping assays or for cloning and production of VSV encoding foreign glycoproteins.
plasmid encoding the VSV antigenome, lacking the G gene, and encoding eGFP, for producing recombinant VSV lacking a glycoprotein for pseudotyping assays or for cloning and production of VSV encoding foreign glycoproteins.
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